How gut bacteria affect Chikungunya virus infection and disease
Gut Microbiota Modulation of Chikungunya Virus Infection and Pathogenesis
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11064082
This study is looking at how the bacteria in your gut might affect how your body responds to the Chikungunya virus, which could help us understand why some people get sicker than others.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11064082 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gut microbiota and Chikungunya virus (CHIKV) infection. It aims to understand how specific gut bacteria influence the immune response to CHIKV, potentially affecting the severity of the disease. The study utilizes advanced techniques, including transgenic mice and microbiome reconstitution, to explore how signals from gut bacteria can modulate the body's antiviral responses and inflammation. By examining these interactions, the research seeks to uncover new insights into the mechanisms of CHIKV pathogenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with Chikungunya virus or are at risk of infection, particularly those with underlying health conditions.
Not a fit: Patients who are not affected by Chikungunya virus or do not have any related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Chikungunya virus infections.
How similar studies have performed: While the specific approach of modulating gut microbiota in relation to CHIKV is novel, similar studies have shown promise in understanding the role of microbiota in other viral infections.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIAMOND, MICHAEL S — WASHINGTON UNIVERSITY
- Study coordinator: DIAMOND, MICHAEL S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alphavirus Infections