How gut bacteria affect cell death in the intestines
Official title: Regulation of the intestinal colonization niche by epithelial cell death
Funded at University of Pennsylvania · NIH-10907482 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut affect the way your intestinal cells live and die, especially when you're dealing with infections like Salmonella, to help us understand how a healthy gut can keep you feeling good and fight off diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 5F32AI176810-02 |
| Project ID | NIH-10907482 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal conditions or those interested in the effects of gut microbiome on health.
✕Less likely to help
Patients with non-gastrointestinal conditions or those not affected by microbiome-related issues may not receive benefits from this research.
What this research studies
This research investigates the relationship between gut bacteria and the regulation of cell death in intestinal epithelial cells. It focuses on how the microbiome influences gene expression related to cell death, particularly during infections like Salmonella. By understanding these mechanisms, the research aims to uncover how gut bacteria can both support normal cell turnover and contribute to disease processes. Patients may benefit from insights into how gut health impacts overall bodily functions and disease resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing gut-related diseases and improving overall health by targeting microbiome interactions.
How similar studies have gone: Other research has shown promising results in understanding the microbiome's role in health and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Miller, Brittany Marie — University of Pennsylvania
- Study coordinator: Miller, Brittany Marie
Related research
Other NIH-funded projects on the same topics.
-
Comparing universal and guideline-directed genetic testing for young adults with cancer
This study is looking at whether a broader genetic test can help young adults with cancer find inherited risks that regular tests might miss, so they can get better treatment and care tailored just for them.
-
Better, searchable data for human pain biology
A data integration center will standardize, combine, and share molecular and cellular data from human pain research to help scientists understand how pain works and to accelerate discoveries.
-
Understanding how sweat glands form and work to help burn and skin injury patients
A study at the University of Pennsylvania looks at how sweat glands develop and function, with the goal of informing treatments for people who suffer traumatic skin injuries.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Understanding how a special airway cell helps protect and repair breathing passages
A researcher is studying a newly found airway cell called the hillock to see how it protects the airways and helps repair them after injury, with the aim of helping people with asthma, COPD, or bronchiectasis.
-
Defining TMJ cartilage progenitors and their regulatory niche for TMJ regeneration
Researchers are studying the cells that could help repair the jaw’s cartilage in TMJ osteoarthritis to lay the groundwork for regenerative therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.