How gut bacteria affect cell death in the intestines
Regulation of the intestinal colonization niche by epithelial cell death
This study is looking at how the bacteria in your gut affect the way your intestinal cells live and die, especially when you're dealing with infections like Salmonella, to help us understand how a healthy gut can keep you feeling good and fight off diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10907482 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut bacteria and the regulation of cell death in intestinal epithelial cells. It focuses on how the microbiome influences gene expression related to cell death, particularly during infections like Salmonella. By understanding these mechanisms, the research aims to uncover how gut bacteria can both support normal cell turnover and contribute to disease processes. Patients may benefit from insights into how gut health impacts overall bodily functions and disease resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal conditions or those interested in the effects of gut microbiome on health.
Not a fit: Patients with non-gastrointestinal conditions or those not affected by microbiome-related issues may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing gut-related diseases and improving overall health by targeting microbiome interactions.
How similar studies have performed: Other research has shown promising results in understanding the microbiome's role in health and disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Miller, Brittany Marie — University of Pennsylvania
- Study coordinator: Miller, Brittany Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.