How gut bacteria affect brain inflammation in people using opioids and living with HIV
Role of Gut Microbiome- Brain Axis in Modulating CNS Inflammasomes in the Neuropathology Produced by Opioid Exposure and HIV
This study is looking at how the bacteria in your gut might affect brain inflammation in people who use opioids and have HIV, with the goal of finding new ways to help improve brain health and cognitive issues for those individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10653833 on NIH RePORTER |
What this research studies
This research investigates the connection between gut bacteria and brain inflammation in individuals who use opioids and are infected with HIV. It focuses on how changes in gut microbiome can lead to inflammation in the central nervous system, potentially worsening cognitive issues. The study examines the role of specific bacterial products in activating immune responses in the brain, which may contribute to neurocognitive disorders. By understanding these mechanisms, the research aims to identify new therapeutic targets for improving brain health in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of opioid use.
Not a fit: Patients who do not have HIV or a history of opioid use are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce brain inflammation and improve cognitive function in patients with HIV and opioid use disorder.
How similar studies have performed: Previous studies have shown promising results in understanding the gut-brain connection, but this specific approach focusing on opioid use and HIV is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Roy, Sabita — University of Miami School of Medicine
- Study coordinator: Roy, Sabita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.