How gut bacteria affect brain inflammation in aging-related diseases
Official title: Impact of the gut microbiome on B cell-mediated neuroinflammation in cerebral amyloid angiopathy
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11054373 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut might affect brain health, especially in people with conditions like Alzheimer's disease, by exploring how these tiny organisms can influence inflammation in the brain as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $696,896 |
| NIH project number | 1R01AG085585-01A1 |
| Project ID | NIH-11054373 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline or diagnosed with conditions like Alzheimer's disease or cerebral amyloid angiopathy.
✕Less likely to help
Patients who are younger or do not have any neurodegenerative conditions may not benefit from this research.
What this research studies
This research investigates the connection between gut bacteria and brain health, particularly focusing on how these microorganisms influence inflammation related to cerebral amyloid angiopathy (CAA) and Alzheimer's disease. By studying the microbiota-gut-brain axis, the research aims to understand how changes in gut bacteria can impact immune responses in the brain, specifically the role of B cells in neuroinflammation. The approach includes examining immune cell behavior and the effects of gut microbiota on brain health in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that harness gut bacteria to improve brain health and reduce neuroinflammation in elderly patients.
How similar studies have gone: Previous studies have shown promising results regarding the influence of gut microbiota on brain health, indicating that this research builds on established findings in the field.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Lee, Juneyoung — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Lee, Juneyoung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.