How gut bacteria affect brain cell barriers
Impact of the Gut Microbiome on Astrocyte Barrier Function
['FUNDING_CAREER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10909795
This study is looking at how the bacteria in your gut might affect brain health, especially for people with multiple sclerosis, by exploring how certain gut bacteria can help protect brain cells and reduce inflammation.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10909795 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gut microbiome and the function of astrocytes, which are crucial cells in the brain that help maintain the blood-brain barrier. The study focuses on how specific gut bacteria, particularly those that produce butyrate, can influence neuroinflammation and potentially improve conditions like multiple sclerosis. By examining both preclinical models and clinical data, the research aims to uncover mechanisms that could lead to new therapeutic strategies for neurological disorders. Patients may benefit from insights into how gut health impacts brain function and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with multiple sclerosis or related neurological conditions.
Not a fit: Patients with neurological disorders unrelated to the gut microbiome may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that harness the gut microbiome to improve brain health and manage neurological diseases.
How similar studies have performed: Previous studies have shown promising results in understanding the gut-brain axis, indicating that this approach could yield significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TANKOU, STEPHANIE — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: TANKOU, STEPHANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.