How gut bacteria affect bone marrow and intestinal inflammation.
Gut microbiome communication with the bone marrow regulates intestinal inflammation.
This study is looking at how certain gut bacteria, especially one called Clostridium scindens, can help improve the immune system in infants with amebiasis, a condition that causes severe diarrhea, by changing how their bone marrow works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11031283 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut bacteria and bone marrow to understand how they influence intestinal inflammation, particularly in infants suffering from amebiasis. The study focuses on a specific gut bacterium, Clostridium scindens, and its potential to alter bone marrow function through epigenetic changes. By examining how these changes can enhance the immune response against Entamoeba histolytica, the research aims to develop novel strategies for preventing severe diarrhea caused by this parasite. The approach includes analyzing the communication pathways between the gut microbiome and bone marrow, as well as the resulting immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under 11 years old who are at risk for or suffering from amebiasis.
Not a fit: Patients who are older than 11 years or those not affected by intestinal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in infants against intestinal infections caused by Entamoeba histolytica.
How similar studies have performed: Other research has shown promising results in understanding the gut microbiome's role in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Burgess, Stacey L — Methodist Hospital Research Institute
- Study coordinator: Burgess, Stacey L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.