How gut bacteria affect bone loss in people with hyperparathyroidism
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
This study is looking at how the variety of bacteria in your gut might affect bone health in people with primary hyperparathyroidism, helping to find out which patients might be more likely to experience bone loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10808859 on NIH RePORTER |
What this research studies
This research investigates the relationship between gut microbiome diversity and bone loss in patients with primary hyperparathyroidism (PHPT). It explores how specific gut bacteria can influence the immune response and contribute to bone density changes. By studying both mice and human populations, the research aims to identify biomarkers that could predict which patients are at risk for significant bone loss. The approach includes analyzing gut bacteria and their effects on immune cells that impact bone health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary hyperparathyroidism who are experiencing or at risk for bone loss.
Not a fit: Patients without hyperparathyroidism or those who do not have significant bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing bone loss in patients with hyperparathyroidism by targeting gut microbiome health.
How similar studies have performed: Previous studies have shown promising results regarding the role of gut microbiome in various health conditions, suggesting potential for success in this novel approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Pacifici, Roberto — Emory University
- Study coordinator: Pacifici, Roberto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.