How gut bacteria adapt during inflammation in bowel disease.
Bacterial adaptions in host-microbe interactions.
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11014951
This study is looking at how inflammation in the gut changes helpful bacteria, especially one called Bacteroides fragilis, to better understand how it might make inflammatory bowel disease (IBD) worse, with the hope of finding new ways to treat IBD.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11014951 on ClinicalTrials.gov |
What this research studies
This research investigates how inflammation in the gut affects the behavior and metabolism of beneficial bacteria, particularly focusing on Bacteroides fragilis. By examining the changes in these bacteria, the study aims to understand their role in worsening inflammatory bowel disease (IBD). The researchers will analyze genetic and functional variations of these bacteria in the inflamed gut environment, which may lead to new microbial therapies for IBD. The approach includes studying the interactions between gut bacteria and the immune system to uncover potential treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.
Not a fit: Patients without inflammatory bowel disease or those with other unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the management of inflammatory bowel disease by targeting gut bacteria.
How similar studies have performed: Other research has shown promising results in understanding gut microbiota's role in inflammatory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHU, HIUTUNG — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CHU, HIUTUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.