How gut bacteria adapt and interact with each other
Mechanisms of adaptation to interbacterial antagonism by the human gut microbiota
This research explores how different types of bacteria in the human gut compete and adapt to each other, helping us understand what makes a healthy gut.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11141062 on NIH RePORTER |
What this research studies
Our gut is home to many different bacteria, and their balance is very important for our health. This project looks closely at how a common group of gut bacteria, called Bacteroidales, fight for space and food using a tiny 'nanoweapon' that can harm other bacteria. We are also learning about how some bacteria develop 'immunity' to these weapons, allowing them to survive and thrive. By understanding these battles and defenses, we hope to learn why each person's gut bacteria are unique and how they maintain their community.
Who could benefit from this research
Good fit: This foundational research is relevant to adults, particularly those interested in the general health and composition of the human gut microbiome.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us better understand how to maintain a healthy balance of gut bacteria and potentially develop new ways to improve gut health.
How similar studies have performed: Previous work by this team and others has shown that these bacterial interactions influence gut composition, and this project builds on those findings to uncover the specific mechanisms involved.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Ross, Benjamin Davidson — Dartmouth College
- Study coordinator: Ross, Benjamin Davidson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.