How growth hormone affects aging and DNA damage in cells
Mechanisms for GH action on epithelial cells
This study is looking at how a special type of growth hormone, called non-pituitary growth hormone, affects aging and DNA damage in cells, especially in the colon, to help us understand how it might play a role in age-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11086659 on NIH RePORTER |
What this research studies
This research investigates the role of non-pituitary growth hormone (npGH) in the aging process and its impact on DNA damage in epithelial cells. The study will utilize advanced techniques, including 3D organoids and microfluidic devices, to observe how npGH is induced by DNA damage in aged tissues and its effects on cell behavior. By analyzing human colon tissue and other models, the research aims to uncover the mechanisms by which npGH contributes to chromosomal instability and aging-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues, particularly those related to DNA damage and cellular aging.
Not a fit: Patients who are younger or do not have age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into aging and potential therapeutic targets for age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of growth hormones in cellular aging, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Melmed, Shlomo — Cedars-Sinai Medical Center
- Study coordinator: Melmed, Shlomo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.