How Gram-negative bacteria build their protective outer layer
Official title: Envelope biogenesis in Gram-negative bacteria
Funded at Ohio State University · NIH-11088287 · Data updated 2026-11-12
This study is looking at how certain bacteria build their protective outer layer, which is important for their survival, and it aims to find new ways to fight infections caused by these bacteria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $379,420 |
| NIH project number | 5R35GM153349-02 |
| Project ID | NIH-11088287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by Gram-negative bacteria, such as E. coli.
✕Less likely to help
Patients with infections caused by Gram-positive bacteria or those not affected by antibiotic resistance may not benefit from this research.
What this research studies
This research investigates the process by which Gram-negative bacteria construct their cell envelope, which is crucial for their growth and survival. The project focuses on understanding the mechanisms of lipid transporters that are responsible for assembling the outer membrane, which is unique due to its composition of lipopolysaccharides. By studying how these lipids are transported through the periplasmic space, the research aims to uncover new insights into bacterial physiology and antibiotic resistance. This knowledge could lead to the development of new strategies to combat bacterial infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of antibiotics against resistant bacterial strains.
How similar studies have gone: Previous research has shown promising results in understanding bacterial envelope biogenesis, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Ruiz, Natividad — Ohio State University
- Study coordinator: Ruiz, Natividad
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.