How Gram-negative bacteria build their protective outer layer
Envelope biogenesis in Gram-negative bacteria
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11088287
This study is looking at how certain bacteria build their protective outer layer, which is important for their survival, and it aims to find new ways to fight infections caused by these bacteria.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11088287 on ClinicalTrials.gov |
What this research studies
This research investigates the process by which Gram-negative bacteria construct their cell envelope, which is crucial for their growth and survival. The project focuses on understanding the mechanisms of lipid transporters that are responsible for assembling the outer membrane, which is unique due to its composition of lipopolysaccharides. By studying how these lipids are transported through the periplasmic space, the research aims to uncover new insights into bacterial physiology and antibiotic resistance. This knowledge could lead to the development of new strategies to combat bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Gram-negative bacteria, such as E. coli.
Not a fit: Patients with infections caused by Gram-positive bacteria or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of antibiotics against resistant bacterial strains.
How similar studies have performed: Previous research has shown promising results in understanding bacterial envelope biogenesis, indicating that this approach has potential for significant advancements.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUIZ, NATIVIDAD — OHIO STATE UNIVERSITY
- Study coordinator: RUIZ, NATIVIDAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.