How Gpr68 affects healing in tendons
Official title: Gpr68 modulation of myofibroblast dynamics during tendon healing
Funded at University of Rochester · NIH-11170672 · Data updated 2026-11-12
This study is looking at how a specific protein called Gpr68 affects the healing of injured tendons, with the goal of finding ways to help the cells that repair tendons work better and reduce scarring, so people can recover more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $164,318 |
| NIH project number | 5R21AR083217-02 |
| Project ID | NIH-11170672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals recovering from tendon injuries who may experience complications due to fibrotic healing.
✕Less likely to help
Patients with tendon injuries that have already healed without complications may not benefit from this research.
What this research studies
This research investigates the role of Gpr68 in the healing process of tendons after injury. It focuses on how myofibroblasts, which are crucial for tendon repair, can be modulated to improve healing outcomes. The study aims to understand the mechanisms behind myofibroblast dynamics and explore potential therapeutic approaches to enhance tendon healing. By examining the behavior of these cells, the research seeks to identify ways to reduce fibrosis and promote better recovery.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve tendon healing and restore function more effectively.
How similar studies have gone: Previous research has shown promise in modulating myofibroblast behavior, indicating that this approach could lead to significant advancements in tendon healing.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Loiselle, Alayna — University of Rochester
- Study coordinator: Loiselle, Alayna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.