How glutathione affects the growth of triple-negative breast cancer
Impact of extracellular glutathione catabolism on triple-negative breast cancer
This study is looking at how a natural antioxidant called glutathione might help triple-negative breast cancer grow, and it aims to find new ways to treat this type of cancer by understanding how glutathione works in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11016928 on NIH RePORTER |
What this research studies
This research investigates the role of extracellular glutathione, a key antioxidant, in the growth of triple-negative breast cancer (TNBC). The study aims to understand how glutathione, which is typically thought to work inside cells, may actually promote tumor growth from outside the cancer cells. Researchers will explore the metabolism of glutathione in the body and its effects on tumor development, using various biochemical techniques to analyze its impact on cancer cell behavior. By examining how glutathione influences the cancer microenvironment, this research could uncover new therapeutic targets for TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple-negative breast cancer who may benefit from novel therapeutic approaches targeting glutathione metabolism.
Not a fit: Patients with other subtypes of breast cancer or those who do not have a diagnosis of breast cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that inhibit glutathione's role in promoting tumor growth, potentially improving outcomes for patients with triple-negative breast cancer.
How similar studies have performed: While the role of antioxidants in cancer therapy is a growing area of interest, this specific approach focusing on extracellular glutathione in TNBC is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Harris, Isaac Spencer — University of Rochester
- Study coordinator: Harris, Isaac Spencer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.