How glutathione affects the growth and harmfulness of Listeria bacteria
The roles of glutathione metabolism in growth and virulence of Listeria monocytogenes
['FUNDING_R21'] · TUFTS UNIVERSITY BOSTON · NIH-10671070
This study is looking at how a substance called glutathione helps the Listeria bacteria grow and make people sick, especially those who are more vulnerable, like older adults, with the goal of finding new ways to prevent infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10671070 on ClinicalTrials.gov |
What this research studies
This research investigates the role of glutathione, a key antioxidant, in the growth and virulence of Listeria monocytogenes, a bacterium that can cause severe illness, particularly in vulnerable populations like the elderly. The study focuses on how Listeria synthesizes or imports glutathione to enhance its ability to cause disease. By understanding the mechanisms behind glutathione's influence on Listeria, researchers aim to identify potential targets for new treatments that could help prevent infections. The approach includes examining the bacterium's genetic and metabolic pathways related to glutathione.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, especially those who are immunocompromised or have underlying health conditions.
Not a fit: Patients who are not elderly or do not have compromised immune systems may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating Listeria infections, particularly in at-risk populations.
How similar studies have performed: Other research has shown promising results in understanding bacterial virulence mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BELITSKY, BORIS R — TUFTS UNIVERSITY BOSTON
- Study coordinator: BELITSKY, BORIS R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.