How glutamine metabolism affects tuberculosis infection
Glutamine metabolism in tuberculosis
This study is looking at how a nutrient called glutamine affects the immune system's ability to fight tuberculosis, with a special focus on certain immune cells, and it hopes to find new ways to boost the body's defenses against this serious infection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rbhs-New Jersey Medical School NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project ID | NIH-10445338 on NIH RePORTER |
What this research studies
This research investigates the role of glutamine metabolism in the immune response to tuberculosis caused by Mycobacterium tuberculosis. It focuses on how changes in the metabolic state of immune cells, particularly macrophages, influence their ability to fight the infection. By utilizing advanced techniques like transcriptomics and metabolomics, the study aims to uncover the mechanisms behind glutamine uptake and its effects on immune cell function during tuberculosis. The findings could lead to new therapeutic strategies to enhance the immune response against this deadly pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis who are seeking new treatment options.
Not a fit: Patients with non-tuberculosis infections or those who do not have an active tuberculosis infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis by enhancing the immune response through metabolic interventions.
How similar studies have performed: Other research has shown promising results in understanding metabolic changes in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, United States
- Rbhs-New Jersey Medical School — Newark, United States (Active)
Researchers
- Principal investigator: Shi, Lanbo — Rbhs-New Jersey Medical School
- Study coordinator: Shi, Lanbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.