How glutamine metabolism affects tuberculosis infection
Official title: Glutamine metabolism in tuberculosis
Funded at Rbhs-New Jersey Medical School · NIH-10445338 · Data updated 2026-11-12
This study is looking at how a nutrient called glutamine affects the immune system's ability to fight tuberculosis, with a special focus on certain immune cells, and it hopes to find new ways to boost the body's defenses against this serious infection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rbhs-New Jersey Medical School NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | July 6, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $237,704 |
| NIH project number | 5R21AI163824-02 |
| Project ID | NIH-10445338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculosis who are seeking new treatment options.
✕Less likely to help
Patients with non-tuberculosis infections or those who do not have an active tuberculosis infection may not benefit from this research.
What this research studies
This research investigates the role of glutamine metabolism in the immune response to tuberculosis caused by Mycobacterium tuberculosis. It focuses on how changes in the metabolic state of immune cells, particularly macrophages, influence their ability to fight the infection. By utilizing advanced techniques like transcriptomics and metabolomics, the study aims to uncover the mechanisms behind glutamine uptake and its effects on immune cell function during tuberculosis. The findings could lead to new therapeutic strategies to enhance the immune response against this deadly pathogen.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis by enhancing the immune response through metabolic interventions.
How similar studies have gone: Other research has shown promising results in understanding metabolic changes in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rbhs-New Jersey Medical School
Newark, United States Active
Researchers
- Principal investigator: Shi, Lanbo — Rbhs-New Jersey Medical School
- Study coordinator: Shi, Lanbo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.