How glutamine metabolism affects muscle stem cell function and aging
Glutamine-driven "bidirectional" metabolism regulates muscle stem cell function
This study is looking at how a substance called glutamine affects muscle stem cells as we get older, and it hopes to find out if boosting glutamine can help these cells work better, which could lead to new ways to treat muscle loss in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11170828 on NIH RePORTER |
What this research studies
This research investigates the role of glutamine metabolism in muscle stem cells and how it changes with age. By analyzing metabolic pathways, the study aims to understand how glutamine contributes to energy generation and cell viability in these stem cells. The researchers will explore whether restoring glutamine metabolism can improve the function of aged muscle stem cells, potentially leading to new therapeutic strategies for age-related muscle degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle degeneration or related conditions.
Not a fit: Patients who are younger and do not have any muscle-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle regeneration and function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways in stem cells, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: White, James P. — Duke University
- Study coordinator: White, James P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.