How glutamine affects bone cell development and bone loss
Official title: Metabolic regulation of osteoclast differentiation and bone resorption
Funded at Ut Southwestern Medical Center · NIH-11047581 · Data updated 2026-11-12
This study is looking at how an important nutrient called glutamine affects bone cells that break down bone, which could help us find new ways to treat bone loss conditions like osteoporosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $588,302 |
| NIH project number | 1R01AR083904-01A1 |
| Project ID | NIH-11047581 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for osteoporosis or those experiencing significant bone loss.
✕Less likely to help
Patients with conditions unrelated to bone metabolism or those who are not at risk for osteoporosis may not benefit from this research.
What this research studies
This research investigates the role of glutamine, an important amino acid, in the development of osteoclasts, which are cells responsible for bone resorption. The study aims to understand how glutamine metabolism influences osteoclast differentiation and bone loss, particularly in conditions like osteoporosis. Researchers will use a mouse model to test the effectiveness of a specific inhibitor on bone resorption and explore the underlying mechanisms of glutamine's effects on these cells. This research could provide insights into new treatments for bone-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating osteoporosis and other bone loss conditions.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways for bone health, suggesting that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Karner, Courtney Michael — Ut Southwestern Medical Center
- Study coordinator: Karner, Courtney Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.