How glucose use by bacteria affects lung immunity in children
Host immunity in the lung is determined by the enhanced utilization of glucose by multi-drug resistant Klebsiella pneumoniae
This study is looking at how tough-to-treat lung infections from a bacteria called Klebsiella pneumoniae affect the lung health of children who need ventilators, to better understand how these infections can make it harder for their lungs to work properly.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11001928 on NIH RePORTER |
What this research studies
This research investigates how multi-drug resistant Klebsiella pneumoniae infections impact lung health in children who rely on ventilators. It focuses on understanding the relationship between bacterial glucose utilization and the inflammatory response in the lungs. By examining how these bacteria alter the metabolic environment, the study aims to uncover mechanisms that lead to persistent infections and impaired lung function. The research employs a combination of laboratory experiments and clinical observations to explore these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are dependent on ventilators and at risk of infections from multi-drug resistant bacteria.
Not a fit: Patients who are not dependent on ventilators or do not have infections caused by multi-drug resistant Klebsiella pneumoniae may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung infections in vulnerable children, potentially reducing the risk of acute deterioration and death.
How similar studies have performed: Previous studies have shown that understanding bacterial metabolism can lead to significant insights into infection management, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Ahn, Danielle — Columbia University Health Sciences
- Study coordinator: Ahn, Danielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.