How glucose sensing affects muscle function and metabolism
Receptor-mediated glucose sensing and skeletal muscle function
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11001216
This study is looking at how our muscles sense sugar and how that affects our overall health, especially for people with type 2 diabetes and obesity, to find new ways to help keep muscles strong and healthy through diet or medication.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11001216 on ClinicalTrials.gov |
What this research studies
This research investigates the role of glucose sensing in skeletal muscle and its impact on metabolic health, particularly in the context of type 2 diabetes and obesity. It explores how nutrient sensing mechanisms are linked to muscle function and plasticity, focusing on the role of a molecule called NAD and its regulation by sweet taste receptors. By understanding these pathways, the research aims to develop new therapies that could prevent or treat muscle degeneration and metabolic dysfunction. Patients may benefit from insights into how their muscle health can be improved through dietary or pharmacological interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing metabolic dysfunction related to type 2 diabetes or obesity.
Not a fit: Patients who are under 21 years old or do not have metabolic dysfunction related to type 2 diabetes or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance muscle function and metabolic health in individuals with type 2 diabetes and obesity.
How similar studies have performed: Other research has shown promising results in understanding the role of glucose sensing in muscle function, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KYRIAZIS, GEORGE — OHIO STATE UNIVERSITY
- Study coordinator: KYRIAZIS, GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus