How glucose metabolism affects brain function and decline in aging and Alzheimer's disease
Official title: Adaptive glycolysis as a regulator of neuronal function and decline
Funded at Yale University · NIH-10890875 · Data updated 2026-11-12
This study is looking at how changes in sugar processing in brain cells might affect memory and thinking as we age or in Alzheimer's disease, using tiny worms to see how these changes happen, which could help find new ways to keep our brain cells healthy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $125,809 |
| NIH project number | 5K99AG083129-02 |
| Project ID | NIH-10890875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing early signs of cognitive decline or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with non-neurological conditions or those not experiencing cognitive decline may not benefit from this research.
What this research studies
This research investigates the role of glucose metabolism in neurons, particularly how changes in glucose uptake during aging and Alzheimer's disease may contribute to neuronal decline. By using advanced genetically-encoded biosensors in the model organism C. elegans, the study aims to visualize and understand the dynamics of glucose metabolism and its relationship with neuronal function. The researchers will explore how neuronal stimulation affects glycolysis and redox balance, which could provide insights into the mechanisms underlying neurodegeneration. This approach may help identify potential therapeutic targets for improving neuronal health in aging and Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving neuronal function and slowing the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding metabolic processes in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wolfe, Aaron — Yale University
- Study coordinator: Wolfe, Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.