How glucose affects blood flow in patients with Postural Tachycardia Syndrome
Official title: Mechanism of Glucose-dependent insulinotropic polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia Syndrome
Funded at Vanderbilt University Medical Center · NIH-11092837 · Data updated 2026-11-12
This study is looking at how eating sugary foods affects blood flow and heart rate in people with Postural Tachycardia Syndrome (POTS), to help understand why these foods can make symptoms like dizziness and a fast heartbeat worse when they stand up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $841,064 |
| NIH project number | 5R01HL159203-04 |
| Project ID | NIH-11092837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Postural Tachycardia Syndrome who experience worsening symptoms after eating carbohydrate-rich meals.
✕Less likely to help
Patients who do not have Postural Tachycardia Syndrome or those who do not experience symptoms related to glucose intake may not benefit from this research.
What this research studies
This research investigates the effects of glucose intake on blood flow and heart rate in patients with Postural Tachycardia Syndrome (POTS). It aims to understand why carbohydrate-rich meals worsen symptoms like dizziness and rapid heartbeat when these patients stand up. By conducting tests that measure blood volume and heart function after glucose consumption, the study seeks to uncover the mechanisms behind these symptoms. The findings could lead to better dietary recommendations and treatments for individuals suffering from POTS.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for POTS patients, enhancing their quality of life.
How similar studies have gone: Previous research has indicated that dietary factors can significantly impact POTS symptoms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Shibao, Cyndya Adriana — Vanderbilt University Medical Center
- Study coordinator: Shibao, Cyndya Adriana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.