How glucocorticoids affect the brain's processing of context in PTSD
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiology
['FUNDING_R01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-10227772
This study is looking at how certain hormones affect the way the brain handles memories and fear in people with PTSD, with the hope of finding new ways to help prevent or treat the condition after someone experiences trauma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-10227772 on ClinicalTrials.gov |
What this research studies
This research investigates how glucocorticoids, a type of hormone, influence the brain's ability to process contextual information in individuals with Post-traumatic Stress Disorder (PTSD). By examining the brain circuits involved in fear responses and contextual processing, the study aims to identify the neurobiological mechanisms that contribute to PTSD. The researchers will explore how these processes can be modified to reduce the risk of developing PTSD after trauma, potentially leading to new treatment and prevention strategies. Patients may participate in assessments that evaluate their responses to various cues in different contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced trauma and are at risk for PTSD, as well as those currently diagnosed with PTSD.
Not a fit: Patients who have not experienced trauma or do not have PTSD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for individuals at risk of developing PTSD.
How similar studies have performed: Other research has shown promise in understanding the neurobiological mechanisms of PTSD, but this specific approach focusing on glucocorticoids and contextual processing is relatively novel.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIBERZON, ISRAEL — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: LIBERZON, ISRAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease