How glucocorticoids affect metabolism in skeletal muscle
Official title: Mechanisms of glucocorticoid-induced metabolic dysfunction in skeletal muscle
Funded at Lsu Pennington Biomedical Research Ctr · NIH-11135638 · Data updated 2026-11-12
This study is looking at how common anti-inflammatory medications called glucocorticoids can affect muscle health by causing issues with blood sugar and fat levels, and it aims to find ways to reduce these side effects for people who use these medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $112,500 |
| NIH project number | 1R56DK141177-01 |
| Project ID | NIH-11135638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are prescribed glucocorticoids for inflammatory conditions and are at risk of developing insulin resistance.
✕Less likely to help
Patients not using glucocorticoids or those without metabolic dysfunction may not benefit from this research.
What this research studies
This research investigates how glucocorticoids, commonly used for their anti-inflammatory effects, can lead to metabolic dysfunction in skeletal muscle. It focuses on understanding the mechanisms by which these medications cause insulin resistance and hyperglycemia through alterations in glucose and lipid metabolism. The study will explore how glucocorticoids increase lipid levels in skeletal muscle, which may impair insulin signaling and contribute to metabolic disorders. By examining these processes, the research aims to identify potential interventions to mitigate these adverse effects.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for patients using glucocorticoids, reducing their risk of insulin resistance and related metabolic issues.
How similar studies have gone: Previous research has indicated that lipid overload in skeletal muscle is linked to insulin resistance, suggesting that this investigation builds on established findings.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Noland, Robert Charles — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Noland, Robert Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.