How glucocorticoids affect blood vessel formation in bone health
Role of glucocorticoid-suppression of preosteoclast PDGF-BB in skeletal angiogenesis
This study is looking at how steroid medications called glucocorticoids affect blood vessel growth in bones, especially in kids who might face bone problems from these drugs, to find better ways to protect their bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11057718 on NIH RePORTER |
What this research studies
This research investigates how glucocorticoids, a type of steroid medication, impact the formation of blood vessels in bones, particularly in children who are at risk for bone-related side effects. The study uses a mouse model to explore the mechanisms by which glucocorticoids suppress the growth of specific blood vessels that are crucial for bone development. By understanding these processes, researchers aim to identify potential targets for new treatments that could mitigate the harmful effects of glucocorticoids on bone health. The findings could lead to improved strategies for managing bone health in patients requiring glucocorticoid therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adults who are prescribed glucocorticoids and are at risk for bone-related complications.
Not a fit: Patients who are not using glucocorticoids or do not have bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent bone damage in patients using glucocorticoids.
How similar studies have performed: Previous research has shown that understanding the role of blood vessels in bone health can lead to significant advancements in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Crane, Janet — Johns Hopkins University
- Study coordinator: Crane, Janet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.