How glucocorticoid receptors affect drug delivery in epilepsy
Molecular Mechanism of Glucocorticoid Receptor, Cytochrome P450, and P-Glycoprotein Axis on Drug Regulation at the Blood-Brain Barrier in Epilepsy with Focal Cortical Dysplasia
This study is looking at how certain receptors in the brain affect how well seizure medications work for people with epilepsy, especially those with a specific brain condition, and aims to find better ways to help these medications reach the brain more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11040097 on NIH RePORTER |
What this research studies
This research investigates how glucocorticoid receptors influence the effectiveness of antiseizure medications by regulating the blood-brain barrier in patients with epilepsy, particularly those with focal cortical dysplasia. The study focuses on the cytochrome P450 and P-glycoprotein pathways, which are crucial for drug metabolism and transport. By understanding these mechanisms, the research aims to identify new therapeutic targets that could enhance drug delivery to the brain, potentially improving seizure management for patients. The approach includes both laboratory studies and animal models to explore the interactions between these biological systems.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epilepsy, particularly those experiencing focal cortical dysplasia and who have not responded well to standard antiseizure medications.
Not a fit: Patients with epilepsy who are well-controlled on their current medications or those with other types of epilepsy not related to focal cortical dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for epilepsy patients who currently struggle with medication resistance.
How similar studies have performed: Previous research has shown promise in targeting similar mechanisms to enhance drug delivery across the blood-brain barrier, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Ghosh, Chaitali — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ghosh, Chaitali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.