How glial cells in the gut affect intestinal movement and disorders
Regulation of enteric motor neurocircuits by enteric glia in health and disease
This study is looking at how special cells in the gut help control how our intestines move, which could help us understand and treat issues like irritable bowel syndrome and inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10887517 on NIH RePORTER |
What this research studies
This research investigates the role of enteric glial cells in regulating the motor functions of the intestine, particularly how they interact with neurons to control gut movements. By examining these interactions, the study aims to uncover the mechanisms behind gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease. The researchers will use advanced techniques, including genetically encoded calcium indicators, to observe how glial cells influence neuronal activity and contribute to conditions like dysmotility. Understanding these processes could lead to new insights into treating gut-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with irritable bowel syndrome, inflammatory bowel disease, or other motility disorders.
Not a fit: Patients with non-gastrointestinal disorders or those without any motility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from gastrointestinal motility disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in the nervous system, suggesting that this approach could yield valuable insights.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Gulbransen, Brian D. — Michigan State University
- Study coordinator: Gulbransen, Brian D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.