How glial cells affect nerve regeneration in the brain and spinal cord
Glial metabolic status regulates axon regeneration in the central nervous system
This study is looking at how certain brain cells called glial cells affect the healing of damaged nerves in people with spinal cord injuries, with the hope of finding new ways to help them recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11071986 on NIH RePORTER |
What this research studies
This research investigates the role of glial cells in the central nervous system and how their metabolic status influences the ability of damaged axons to regenerate. By examining the interactions between neurons and glial cells, the study aims to identify new therapeutic pathways that could enhance nerve regeneration following spinal cord injuries. The approach involves analyzing the biochemical environment created by glial cells and its impact on neuronal growth. Patients with spinal cord injuries may benefit from insights gained through this research, potentially leading to new treatments that improve recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced spinal cord injuries and are dealing with paralysis or significant motor dysfunction.
Not a fit: Patients with conditions unrelated to spinal cord injuries or those who have not experienced any form of axonal damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treatments that promote nerve regeneration and recovery for individuals with spinal cord injuries.
How similar studies have performed: Previous research has shown promise in understanding the role of glial cells in nerve regeneration, but this specific approach is exploring novel pathways that have not been extensively tested.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Song, Yuanquan — Children's Hosp of Philadelphia
- Study coordinator: Song, Yuanquan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.