How gestational diabetes affects the health of offspring through stem cells
Official title: Diabetic Memory in Hematopoietic Stem Cells
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11002323 · Data updated 2026-11-12
This study is looking at how gestational diabetes in mothers might affect their children's health later in life, especially by changing certain blood cells, and it aims to find ways to help prevent any long-term health issues for those kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 15, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $399,184 |
| NIH project number | 5R01DK133145-03 |
| Project ID | NIH-11002323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who were born to mothers with gestational diabetes and are now experiencing health issues related to metabolic disorders.
✕Less likely to help
Patients who do not have a family history of gestational diabetes or related metabolic conditions may not benefit from this research.
What this research studies
This research investigates the long-term effects of gestational diabetes on the health of offspring, focusing on how hematopoietic stem cells (HSCs) are altered by maternal diabetes. By using mouse models that mimic human gestational diabetes, the study aims to understand the mechanisms behind the transmission of health issues from mothers to their children. The researchers will explore how changes in HSCs can lead to persistent health problems in adulthood, even in the absence of diabetes. This work could provide insights into preventing or mitigating these long-term effects in children born to mothers with gestational diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing long-term health issues in children born to mothers with gestational diabetes.
How similar studies have gone: Previous research has shown that maternal health conditions can have lasting effects on offspring, but this specific approach focusing on hematopoietic stem cells is relatively novel.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Reynaud, Damien — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Reynaud, Damien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.