How genomes fold and regulate in multicellular organisms
Genome Folding and Regulation in Diploid Multicellular Organisms
This study is looking at how different types of cells grow from one single cell in living organisms, and it aims to understand how changes in our genes can lead to health issues like developmental disorders or cancer, which could help us find better ways to diagnose these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11083039 on NIH RePORTER |
What this research studies
This research investigates the complex processes by which different cell types develop from a single cell in multicellular organisms. It focuses on understanding how the organization of genomes and gene activity changes over time, and how disruptions in these processes can lead to developmental disorders or cancers. By using advanced techniques like haplotype-specific omics and single-cell imaging, the research aims to uncover how parental genomes contribute to cell identity and function. This knowledge could help identify the underlying causes of various diseases and improve diagnostic methods.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with congenital abnormalities, developmental disorders, or cancers linked to genomic disruptions.
Not a fit: Patients with conditions unrelated to genomic structure or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of developmental disorders and cancers.
How similar studies have performed: Other research has shown promising results in understanding genome organization and its implications for health, making this approach both relevant and potentially impactful.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Erceg, Jelena — University of Connecticut Storrs
- Study coordinator: Erceg, Jelena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.