How genetics, diet, and age affect Alzheimer's disease and aging
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity
This study is looking at how things like your genes, what you eat, your age, and whether you're male or female can affect the amount of mitochondrial DNA in your cells, which might help us understand Alzheimer's disease and aging better, so we can find ways to help people live healthier, longer lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10983352 on NIH RePORTER |
What this research studies
This research investigates how various factors such as genetic variants, diet, age, and sex interact with mitochondrial DNA copy number to influence Alzheimer's disease and aging-related conditions. By studying genetically engineered mouse models, the research aims to uncover the mechanisms behind these interactions and their impact on health outcomes. The study will analyze tissue samples from different ages and dietary conditions to identify key genetic and environmental influences on aging and Alzheimer's disease. This could lead to a better understanding of how to promote longevity and mitigate age-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those experiencing early signs of cognitive decline.
Not a fit: Patients with non-age-related cognitive impairments or those not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into personalized strategies for preventing or delaying Alzheimer's disease and improving overall health in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial function in aging and Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Ashbrook, David George — University of Tennessee Health Sci Ctr
- Study coordinator: Ashbrook, David George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.