How genetics and inflammation affect cognitive development in children born extremely preterm
Genetic and Epigenetic Effects on Childhood Cognitive Trajectories
This study is looking at how being born very early affects children's thinking skills as they grow up, and it’s for families with kids who were born extremely preterm; we want to see how genes and other factors might help us understand their learning and development from ages 2 to 17.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami Coral Gables NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10894171 on NIH RePORTER |
What this research studies
This research investigates the cognitive development of children born extremely preterm, focusing on how genetic and epigenetic factors influence their cognitive trajectories from ages 2 to 17. The study aims to identify immune factors and genetic variants that predict cognitive function outcomes, particularly in relation to neonatal inflammation. By examining these links, the research seeks to understand the patterns of cognitive impairment and improvement in this vulnerable population. Participants will undergo assessments that include genetic testing and cognitive evaluations over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 2 to 17 who were born extremely preterm (less than 28 weeks gestation).
Not a fit: Patients who were born full term or those outside the age range of 2 to 17 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that improve cognitive outcomes for children born extremely preterm.
How similar studies have performed: Previous research has shown promising results in understanding cognitive trajectories in preterm infants, but this specific genetic and epigenetic approach is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami Coral Gables — Coral Gables, United States (Active)
Researchers
- Principal investigator: Santos, Hudson — University of Miami Coral Gables
- Study coordinator: Santos, Hudson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.