How genetics and inflammation affect breathing control
Official title: Rest/Active Phase Specificity of APOE4 and Inflammation on Respiratory Plasticity
Funded at University of Florida · NIH-10948545 · Data updated 2026-11-12
This study is looking at how certain genes and inflammation affect breathing, especially for people with spinal cord injuries and ALS, to find new ways to help them breathe better after facing challenges like low oxygen levels.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $131,733 |
| NIH project number | 1K99HL175029-01 |
| Project ID | NIH-10948545 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with spinal cord injuries or ALS who may benefit from enhanced respiratory function.
✕Less likely to help
Patients without spinal cord injuries or ALS, or those who do not carry the APOE4 allele, may not receive benefits from this research.
What this research studies
This research investigates the role of genetic factors, particularly the APOE4 allele, and inflammation in the mechanisms that control breathing. It focuses on understanding how these factors influence respiratory motor plasticity, which is the ability of the respiratory system to adapt and improve after challenges like hypoxia. By using advanced techniques in neuroscience and respiratory physiology, the research aims to identify molecular targets that could lead to new treatments for individuals with spinal cord injuries and ALS, enhancing their breathing capabilities.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve breathing function in patients with spinal cord injuries and ALS.
How similar studies have gone: Previous research has shown promising results in understanding respiratory plasticity, but this specific approach focusing on genetic factors and inflammation is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Marciante, Alexandria — University of Florida
- Study coordinator: Marciante, Alexandria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.