How genetic variations affect immune responses in organ transplantation
Official title: TNFRSF13B polymorphisms and immunity to transplantation
Funded at Case Western Reserve University · NIH-11269919 · Data updated 2026-11-12
This study is looking at how certain genes might affect how well kidney transplants work for patients, helping doctors find out who might do better or face complications after their surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $768,714 |
| NIH project number | 7R01AI173950-03 |
| Project ID | NIH-11269919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received a kidney transplant and are willing to provide DNA samples for analysis.
✕Less likely to help
Patients who have not undergone organ transplantation or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research explores the role of genetic variations in the TNFRSF13B gene and how they influence the immune response to organ transplants. By analyzing DNA samples from kidney transplant recipients, the study aims to identify specific genetic markers that predict whether a patient will experience successful transplantation or develop complications like antibody-mediated rejection. The researchers will connect these genetic profiles with clinical outcomes to better understand the mechanisms behind transplant immunity. This could lead to more personalized approaches in managing transplant patients based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection in transplant patients.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors influencing transplant outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Cascalho, Marilia Isabel — Case Western Reserve University
- Study coordinator: Cascalho, Marilia Isabel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.