How genetic variations affect decision-making differently in male and female brains
Sex-biased impacts of 16p11.2 variants on reward-guided choice
This study is looking at how certain genetic differences affect how male and female mice make decisions, especially when it comes to rewards, to help us understand why boys and girls might be more vulnerable to certain brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10829861 on NIH RePORTER |
What this research studies
This research investigates how genetic variations at the 16p11.2 locus influence decision-making processes in male and female brains. By using an animal model, specifically mice, the study examines the differences in reward-guided choices between male and female subjects with a specific genetic alteration. The researchers will analyze the functional activation of brain circuits involved in these decision-making processes to understand the underlying mechanisms that contribute to neurodevelopmental disorders. This approach aims to uncover the biological factors that lead to different vulnerabilities in males and females regarding neuropsychiatric conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with a known genetic variant at the 16p11.2 locus.
Not a fit: Patients without neurodevelopmental disorders or those not carrying the 16p11.2 genetic variant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for neurodevelopmental disorders based on sex and genetic background.
How similar studies have performed: Previous research has shown that understanding genetic influences on behavior can lead to significant advancements in treating neurodevelopmental disorders, indicating potential success for this approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Grissom, Nicola — University of Minnesota
- Study coordinator: Grissom, Nicola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.