How genetic mutations affect the risk of a rare lymphoma in women with textured breast implants
Impact of germline mutations on the development of breast-implant associated anaplastic large cell lymphoma (BIA-ALCL) in women with textured breast implants
This study is looking at how certain genetic changes might be linked to a rare type of cancer that can develop in women with textured breast implants, and it's for women who have had these implants to help understand their risks better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10685505 on NIH RePORTER |
What this research studies
This research investigates the link between genetic mutations and the development of breast implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) in women who have textured breast implants. By analyzing genetic information from patients, the study aims to identify specific mutations that may increase the risk of developing this rare form of lymphoma. The approach includes collecting data from women with a history of BIA-ALCL and comparing their genetic profiles to those without the condition. This could help in understanding the underlying causes and improving risk assessment for women with breast implants.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have textured breast implants and may have experienced symptoms related to BIA-ALCL.
Not a fit: Patients who do not have textured breast implants or those who have not been diagnosed with BIA-ALCL are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk prediction and management strategies for women with textured breast implants.
How similar studies have performed: Previous research has shown a correlation between certain genetic factors and the development of other lymphomas, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Ghione, Paola — Sloan-Kettering Inst Can Research
- Study coordinator: Ghione, Paola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.