How genetic factors influence brain metabolism and Alzheimer's risk
Official title: Biochemical Consequences of Regiospecific Metabolic Bias in the Brain
Funded at Brigham Young University · NIH-10796832 · Data updated 2026-11-12
This study is looking at how different versions of a gene called ApoE might affect the risk of developing Alzheimer's and heart problems, and it’s for anyone interested in understanding how these genetic differences can influence brain health and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | May 15, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $584,286 |
| NIH project number | 5R01AG066874-05 |
| Project ID | NIH-10796832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those carrying specific ApoE genetic variants.
✕Less likely to help
Patients without any genetic predisposition to Alzheimer's disease or those who are not at risk due to other factors may not benefit from this research.
What this research studies
This research investigates the role of Apolipoprotein E (ApoE) genetic variants in the development of Alzheimer's disease and cardiovascular issues. It aims to understand how these variants affect lipid transport in the brain and how this transport influences cognitive function and memory. By examining the metabolic pathways impacted by ApoE polymorphisms, the study seeks to identify potential interventions that could modify metabolic biases and reduce the risk of neurodegeneration. The research combines genetic analysis with innovative methods to monitor lipid and protein turnover in living subjects.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Alzheimer's disease and improving brain health through targeted lifestyle and dietary interventions.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between ApoE variants and Alzheimer's risk, indicating that this approach has potential for significant findings.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Price, John C. — Brigham Young University
- Study coordinator: Price, John C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.