How genetic factors and low oxygen levels affect lung blood vessel cells in pulmonary hypertension
Official title: Genetic and hypoxic control of a lncRNA axis orchestrates endothelial reprogramming in pulmonary hypertension
Funded at University of Pittsburgh at Pittsburgh · NIH-11094090 · Data updated 2026-11-12
This study is looking at how a certain gene related to lung health might play a role in pulmonary hypertension, especially when there are changes in our genes or low oxygen levels, to help find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $687,185 |
| NIH project number | 5R01HL151228-03 |
| Project ID | NIH-11094090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Group 1 or Group 3 pulmonary hypertension, particularly those with specific genetic markers.
✕Less likely to help
Patients with other forms of pulmonary hypertension not related to the genetic factors being studied may not benefit from this research.
What this research studies
This research investigates the role of a specific long non-coding RNA (lncRNA) in the development of pulmonary hypertension (PH), a serious condition affecting blood vessels in the lungs. The study focuses on how genetic variations and low oxygen levels influence the expression of this lncRNA and its associated gene, which are believed to contribute to the disease's progression. By using advanced techniques like genome editing and studying cells derived from patients, the research aims to uncover the mechanisms behind PH and identify potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary hypertension, improving outcomes for patients suffering from this condition.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and molecular mechanisms of pulmonary hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Chan, Stephen Y — University of Pittsburgh at Pittsburgh
- Study coordinator: Chan, Stephen Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.