How genetic differences affect the use of birth control pills
Official title: Influence of genetic variants on the pharmacokinetics and pharmacodynamics of combined oral contraceptive pill users
Funded at Yale University · NIH-11110362 · Data updated 2026-11-12
This study is looking at how your genes might affect how well birth control pills work for you and how safe they are, and it's for women who use these pills to help create better, personalized options based on individual genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 7, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $607,585 |
| NIH project number | 5R01HD111436-02 |
| Project ID | NIH-11110362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who are currently using combined oral contraceptive pills.
✕Less likely to help
Patients who are not using birth control pills or are postmenopausal may not benefit from this research.
What this research studies
This research investigates how genetic variations influence the effectiveness and safety of combined oral contraceptive pills (COCPs) among women. By creating a new biobank of 700 women who use COCPs, the study aims to gather important data on how individual genetics can affect responses to these commonly prescribed medications. The research will analyze the relationship between genetic factors and the pharmacokinetics (how the body processes the drug) and pharmacodynamics (how the drug affects the body) of COCPs. This could lead to more personalized contraceptive options for women based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer contraceptive options tailored to individual genetic profiles.
How similar studies have gone: Previous pharmacogenomic research has shown success in developing clinical guidelines for other medications, indicating potential for similar advancements in contraceptive use.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Lazorwitz, Aaron — Yale University
- Study coordinator: Lazorwitz, Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.