How genetic differences affect the body's response to ozone air pollution
Regulatory Genomics of Ozone Air Pollution Response in Vitro and In Vivo
This study is looking at how breathing in ozone, a type of air pollution, affects lung health and whether our genes play a role in how we react to it, so we can better understand who might be more at risk from air pollution.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11040986 on NIH RePORTER |
What this research studies
This research investigates how exposure to ozone, a common air pollutant, impacts lung health and function, particularly focusing on genetic factors that may influence individual responses. By using human bronchial epithelial cells in laboratory settings, the study aims to identify specific genetic variations that lead to differences in inflammation and lung injury caused by ozone exposure. The researchers will analyze gene expression changes in these cells to understand the underlying mechanisms of ozone's effects on health. This approach could help identify individuals who are more susceptible to the harmful effects of air pollution.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of respiratory conditions or those living in areas with high ozone levels.
Not a fit: Patients who do not have respiratory issues or who are not exposed to significant levels of ozone pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of individuals at risk for respiratory issues due to ozone exposure, enabling targeted prevention strategies.
How similar studies have performed: Previous studies have shown that genetic factors can influence responses to environmental pollutants, suggesting that this research could build on established findings.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Kelada, Samir — Univ of North Carolina Chapel Hill
- Study coordinator: Kelada, Samir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.