How genetic differences affect COVID-19 responses and outcomes
MHC Variation in Host Response to SARS-CoV2 and COVID-19 Outcomes
This study is looking at how certain genes related to your immune system might affect how you respond to COVID-19, and it's for people who have donated bone marrow and already have their genetic information on file; by using a smartphone app, you'll help researchers understand symptoms and outcomes to improve vaccines and treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10870188 on NIH RePORTER |
What this research studies
This research investigates how variations in the Human Leukocyte Antigen (HLA) region of the human genome influence the immune response to COVID-19. By utilizing a smartphone app, researchers will collect data on COVID-19 symptoms and outcomes from a large group of volunteer bone marrow donors who already have HLA genotyping data. This approach allows for a detailed examination of how genetic factors may affect disease severity and response to treatment, potentially leading to better vaccine development and immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are volunteer bone marrow donors with pre-existing HLA genotyping data.
Not a fit: Patients who do not have HLA genotyping data or are not part of the bone marrow donor registry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies and improved vaccine efficacy for COVID-19 based on individual genetic profiles.
How similar studies have performed: Other research has shown success in understanding genetic factors in infectious diseases, making this approach promising but still relatively novel in the context of COVID-19.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Hollenbach, Jill Allison — University of California, San Francisco
- Study coordinator: Hollenbach, Jill Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.