How genetic changes in p53 affect cancer growth and treatment
The impact of coding region variants on mutant p53 biology
This study is looking at how certain changes in a gene called p53 affect cancer cells and how they respond to treatments, with the hope of finding better, more personalized therapies for patients with cancers linked to these gene changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10745926 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations in the p53 gene influence the behavior of cancer cells and their response to treatments. By focusing on mutations that alter the p53 protein, the study aims to understand how these changes contribute to tumor growth and metastasis. The researchers will explore the effects of two specific genetic variants on the p53 protein's function and how they may impact the effectiveness of drugs designed to restore normal p53 activity in tumors. Patients may benefit from insights that could lead to more targeted therapies for cancers driven by mutant p53.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with tumors that have mutations in the p53 gene.
Not a fit: Patients without p53 mutations or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cancers associated with mutant p53.
How similar studies have performed: Previous research has shown promise in targeting mutant p53, indicating that this approach may lead to significant advancements in cancer treatment.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Murphy, Maureen E. — Wistar Institute
- Study coordinator: Murphy, Maureen E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.