How genetic changes in certain proteins affect prostate cancer in African American men
Functional Consequences of Racially Associated Ephrin Alterations on the Prostate Tumor Microenvironment
This study is looking at why African American men are more likely to get prostate cancer than Caucasian men by exploring certain genetic changes that might affect how cancer grows, and it invites patients to help by sharing tissue samples or joining in on research about these genetic factors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project ID | NIH-10670886 on NIH RePORTER |
What this research studies
This research investigates the biological factors contributing to the higher rates of prostate cancer in African American men compared to Caucasian men. It focuses on specific genetic alterations in the EphB2 protein, which may disrupt normal cell signaling and promote cancer progression. By examining how these changes affect both cancer cells and the surrounding tumor microenvironment, the study aims to uncover the mechanisms behind these racial disparities in prostate cancer outcomes. Patients may be involved in providing tissue samples or participating in studies that explore these genetic factors.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men who are at risk for or diagnosed with prostate cancer.
Not a fit: Patients who are not African American or those without prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and targeted treatments for prostate cancer in African American men.
How similar studies have performed: Previous research has indicated that genetic factors play a significant role in cancer disparities, suggesting that this approach may yield valuable insights.
Where this research is happening
Shreveport, United States
- Louisiana State Univ Hsc Shreveport — Shreveport, United States (Active)
Researchers
- Principal investigator: Franco Coronel, Omar — Louisiana State Univ Hsc Shreveport
- Study coordinator: Franco Coronel, Omar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.