How genetic changes from retrotransposition affect cancer development
Official title: Consequences of retrotransposition on genome integrity
Funded at Dana-Farber Cancer Inst · NIH-10895476 · Data updated 2026-11-12
This study is looking at how certain genetic changes that happen in our DNA might cause different types of cancer, and it hopes to find new ways to help patients by understanding these changes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $702,485 |
| NIH project number | 5R01CA276112-02 |
| Project ID | NIH-10895476 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancers such as adenocarcinoma of the esophagus or colon cancer, particularly those with a history of Barrett's esophagus or related conditions.
✕Less likely to help
Patients with cancers unrelated to genomic instability or those without a history of the specified conditions may not benefit from this research.
What this research studies
This research investigates the role of retrotransposition, a process where genetic elements move within the genome, in the development of various cancers, particularly focusing on how these movements can lead to mutations and genomic instability. By using both laboratory models and computational analyses, the researchers aim to understand how these genetic changes contribute to cancer evolution and tumor formation. Patients may benefit from insights gained about the mechanisms behind their cancers, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for cancers associated with genomic instability.
How similar studies have gone: Previous research has shown that understanding genetic variations and their impact on cancer can lead to significant advancements in treatment, suggesting that this approach has the potential for success.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Burns, Kathleen H — Dana-Farber Cancer Inst
- Study coordinator: Burns, Kathleen H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.