How genetic changes affect gene control in COPD
Leveraging Variant-perturbed Gene Regulation to Support Precision Medicine in COPD
The team will map how genetic differences change gene and microRNA regulation to point to new treatment targets for people with COPD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11323503 on NIH RePORTER |
What this research studies
Researchers are studying how genetic variants change the way genes and microRNAs control lung cells in COPD. They build computational network maps that combine patient genetic and molecular data with laboratory information. Those disrupted network patterns will be matched to drug-response databases like the Connectivity Map to nominate existing compounds or molecular targets that might reverse harmful changes. The overall aim is to generate leads for more personalized COPD treatments based on each person's molecular profile.
Who could benefit from this research
Good fit: People living with COPD who can provide genetic information and blood or tissue samples, and who can work with Brigham and Women's Hospital, would be ideal candidates.
Not a fit: People without COPD, those unwilling to provide genetic or tissue samples, or those seeking immediate clinical treatments are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could point to targeted therapies tailored to the molecular causes of an individual's COPD.
How similar studies have performed: Related network-based and Connectivity Map approaches have identified candidate drugs in other diseases, but applying them to COPD and miRNA–variant interactions is a relatively new approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Glass, Kimberly Renee — Brigham and Women's Hospital
- Study coordinator: Glass, Kimberly Renee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.