How genetic and physical traits of the influenza virus affect its spread in cells
Official title: Genetic and biophysical mechanisms that control influenza virus cellular multiplicity of infection
Funded at Washington University · NIH-11003294 · Data updated 2026-11-12
This study is looking at how different features of the flu virus affect how it infects our cells and spreads in our bodies, helping us understand how the virus interacts with our immune system and how infections progress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | February 16, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $377,088 |
| NIH project number | 5R01AI171445-03 |
| Project ID | NIH-11003294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of influenza infection, including those with weakened immune systems or underlying health conditions.
✕Less likely to help
Patients who are not at risk for influenza or those who have already been vaccinated may not receive direct benefits from this research.
What this research studies
This research investigates how the genetic and biophysical characteristics of the influenza virus influence its ability to infect cells and spread within the body. By examining the roles of specific viral proteins, the study aims to understand how variations in viral load per cell can affect the host's immune response and the progression of infection. The research employs advanced techniques to analyze the interactions between the virus and host cells, providing insights into the mechanisms of viral spread and infection dynamics.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating influenza infections.
How similar studies have gone: Previous research has shown success in understanding viral spread mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Vahey, Michael D — Washington University
- Study coordinator: Vahey, Michael D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.