How genetic and immune factors affect C. difficile colitis
Regulation of C. difficile colitis by host genetic and immune factors
This study is looking at how certain genes and the immune system affect how severe C. difficile colitis can be, which is an intestinal infection, to help find out who might be at greater risk and how to create better treatments for it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10897925 on NIH RePORTER |
What this research studies
This research investigates how genetic variations and immune responses influence the severity of C. difficile colitis, a serious intestinal infection. The study focuses on the leptin receptor pathway and a specific genetic variant that may lead to increased inflammation and tissue damage during infection. By examining these factors, researchers aim to understand the underlying mechanisms that contribute to disease outcomes. The findings could help identify patients at higher risk and develop targeted therapies to improve treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced C. difficile infections and may have genetic predispositions affecting their immune response.
Not a fit: Patients who have not had C. difficile infections or those with unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for patients suffering from C. difficile colitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic factors in infectious diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Madan, Rajat — University of Cincinnati
- Study coordinator: Madan, Rajat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.