How genetic and environmental factors interact to influence human health
Gene-Environment Interactions in Human Evolution and Complex Traits
This study is looking at how our genes and the environment we live in work together to influence diseases, using old DNA and data from a large group of people, so we can better understand how these factors affect our health today.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11081699 on NIH RePORTER |
What this research studies
This research investigates the interactions between genetic variations and environmental factors that contribute to human diseases. By analyzing ancient DNA and utilizing large population cohorts, the project aims to identify how these interactions have evolved and how they affect complex traits today. The researchers will develop advanced computational tools to analyze data from the UK Biobank, focusing on the relationship between genetics and lifestyle factors. The findings will be made publicly available to enhance understanding of disease causation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of complex diseases or those interested in understanding how their genetics and environment may influence their health.
Not a fit: Patients with rare genetic disorders that are not influenced by environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of disease mechanisms and more effective prevention strategies tailored to individual genetic and environmental profiles.
How similar studies have performed: Previous research has shown success in identifying gene-environment interactions, but this project aims to expand on those findings with a novel approach using ancient DNA and large-scale data analysis.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Ye, Kaixiong — University of Georgia
- Study coordinator: Ye, Kaixiong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.