How genetic and environmental factors affect immune cells in children with biliary fibrosis.
Official title: Genetic and microenvironmental regulation of macrophage functions driving biliary fibrosis in pediatric PSC
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11048512 · Data updated 2026-11-12
This study is looking at how genes and the surrounding environment affect immune cells in kids with primary sclerosing cholangitis, a condition that can harm the liver, to find new ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 15, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $533,386 |
| NIH project number | 2R01DK095001-10 |
| Project ID | NIH-11048512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients diagnosed with primary sclerosing cholangitis and experiencing biliary fibrosis.
✕Less likely to help
Patients without a diagnosis of primary sclerosing cholangitis or those who are not experiencing biliary fibrosis may not benefit from this research.
What this research studies
This research investigates how genetic and microenvironmental factors influence the functions of macrophages, a type of immune cell, in driving biliary fibrosis in pediatric patients with primary sclerosing cholangitis (PSC). The study aims to understand the underlying mechanisms that contribute to this condition, which can lead to liver damage. By analyzing patient samples and utilizing advanced laboratory techniques, the research seeks to identify potential therapeutic targets that could improve outcomes for affected children.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent biliary fibrosis in children with PSC.
How similar studies have gone: While the specific focus on pediatric biliary fibrosis is relatively novel, there have been successful studies exploring macrophage functions in other fibrotic conditions.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Miethke, Alexander — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Miethke, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.