How genetic and environmental factors affect egg development in women
The impact of genetic and environmental factors on meiotic prophase in the human female
['FUNDING_R01'] · WASHINGTON STATE UNIVERSITY · NIH-10864006
This study is looking at what causes mistakes in the early development of eggs in women, focusing on how genetics and exposure to certain chemicals might affect egg quality, to help understand issues that can lead to birth defects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10864006 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that contribute to errors during the early stages of egg development in women. By analyzing a large database of human female meiotic data collected over a decade, the study aims to understand how both genetic predispositions and environmental influences, such as exposure to endocrine disrupting chemicals, impact the quality of eggs. The researchers will examine maternal and fetal biospecimens to identify patterns and correlations between chemical exposure and meiotic errors. This comprehensive approach seeks to shed light on the underlying causes of conditions like aneuploidy, which can lead to birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research include women under 21 years old who may be affected by reproductive health issues related to chromosomal abnormalities.
Not a fit: Patients who are not female or those over the age of 21 may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of reproductive issues related to chromosomal abnormalities in women.
How similar studies have performed: Previous research has shown promising results in understanding the impact of environmental factors on reproductive health, making this approach both relevant and potentially impactful.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUNT, PATRICIA — WASHINGTON STATE UNIVERSITY
- Study coordinator: HUNT, PATRICIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.