How genes that affect multiple traits influence immune system evolution
The influence of coevolutionary feedbacks on the origins and maintenance of genetic pleiotropy
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY · NIH-11091175
This study is looking at how one gene can affect different parts of the immune system, helping us understand how these genes change over time to fight off germs, and it’s for anyone interested in how our bodies adapt to illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11091175 on ClinicalTrials.gov |
What this research studies
This research investigates the phenomenon of pleiotropy, where a single gene impacts multiple traits, particularly in the context of immune systems. By examining genomic data from various model organisms, the study aims to understand how these genes evolve and adapt in response to pathogens. The researchers will utilize computational modeling and analysis to explore the balance between beneficial and detrimental effects of these genes on immune function. This approach may reveal insights into the evolutionary pressures that shape immune responses across different species.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in the genetic factors influencing immune responses.
Not a fit: Patients with conditions unrelated to immune system function or genetic pleiotropy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune system evolution, potentially leading to improved treatments for autoimmune diseases.
How similar studies have performed: Previous research has shown that understanding genetic pleiotropy can significantly impact our knowledge of evolutionary biology, suggesting that this approach has potential for meaningful insights.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TATE, ANN THOMAS — VANDERBILT UNIVERSITY
- Study coordinator: TATE, ANN THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.